Influenza epidemiology and characterization of influenza viruses in patients seeking treatment for acute fever in Cambodia
Identifieur interne : 002D73 ( Main/Exploration ); précédent : 002D72; suivant : 002D74Influenza epidemiology and characterization of influenza viruses in patients seeking treatment for acute fever in Cambodia
Auteurs : P. J. Blair [Indonésie] ; T. F. Wierzba [Cambodge] ; S. Touch [Cambodge] ; S. Vonthanak [Cambodge] ; X. Xu [États-Unis] ; R. J. Garten [États-Unis] ; M. A. Okomo-Adhiambo [États-Unis] ; A. I. Klimov [États-Unis] ; M. R. Kasper [Indonésie] ; S. D. Putnam [Indonésie]Source :
- Epidemiology and Infection [ 0950-2688 ] ; 2010-02.
Abstract
The epidemiology, symptomology, and viral aetiology of endemic influenza remain largely uncharacterized in Cambodia. In December 2006, we established passive hospital-based surveillance to identify the causes of acute undifferentiated fever in patients seeking healthcare. Fever was defined as tympanic membrane temperature >38°C. From December 2006 to December 2008, 4233 patients were screened for influenza virus by real-time reverse-transcriptase polymerase chain reaction (rRT–PCR). Of these patients, 1151 (27·2%) were positive for influenza. Cough (68·8% vs. 50·5%, P<0·0001) and sore throat (55·0% vs. 41·9%, P<0·0001) were more often associated with laboratory-confirmed influenza-infected patients compared to influenza-negative enrollees. A clear influenza season was evident between July and December with a peak during the rainy season. Influenza A and B viruses were identified in 768 (66·3%) and 388 (33·7%) of the influenza-positive population (n=1153), respectively. In December 2008, passive surveillance identified infection of the avian influenza virus H5N1 in a 19-year-old farmer from Kandal province who subsequently recovered. From a subset of diagnostic samples submitted in 2007, 15 A(H1N1), seven A(H3N2) and seven B viruses were isolated. The predominant subtype tested was influenza A(H1N1), with the majority antigenically related to the A/Solomon Island/03/2006 vaccine strain. The influenza A(H3N2) isolates and influenza B viruses analysed were closely related to A/Brisbane/10/2007 or B/Ohio/01/2005 (B/Victoria/2/87-lineage) vaccine strains, respectively. Phylogenetic analysis of the HA1 region of the HA gene of influenza A(H1N1) viruses demonstrated that the Cambodian isolates belonged to clade 2C along with representative H1N1 viruses circulating in SE Asia at the time. These viruses remained sensitive to oseltamivir. In total, our data suggest that viral influenza infections contribute to nearly one-fifth of acute febrile illnesses and demonstrate the importance of influenza surveillance in Cambodia.
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DOI: 10.1017/S095026880999063X
Affiliations:
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Touch</name><affiliation wicri:level="1"><country xml:lang="fr">Cambodge</country><wicri:regionArea>Communicable Diseases Control Department, Kingdom of Cambodia Ministry of Health, Phnom Penh</wicri:regionArea><wicri:noRegion>Phnom Penh</wicri:noRegion></affiliation></author><author><name sortKey="Vonthanak, S" sort="Vonthanak, S" uniqKey="Vonthanak S" first="S." last="Vonthanak">S. Vonthanak</name><affiliation wicri:level="1"><country xml:lang="fr">Cambodge</country><wicri:regionArea>National Institute of Public Health, Kingdom of Cambodia Ministry of Health, Phnom Penh</wicri:regionArea><wicri:noRegion>Phnom Penh</wicri:noRegion></affiliation></author><author><name sortKey="Xu, X" sort="Xu, X" uniqKey="Xu X" first="X." last="Xu">X. 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Infect.</title><idno type="ISSN">0950-2688</idno><idno type="eISSN">1469-4409</idno><imprint><publisher>Cambridge University Press</publisher><pubPlace>Cambridge, UK</pubPlace><date type="published" when="2010-02">2010-02</date><biblScope unit="volume">138</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="199">199</biblScope><biblScope unit="page" to="209">209</biblScope></imprint><idno type="ISSN">0950-2688</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0950-2688</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The epidemiology, symptomology, and viral aetiology of endemic influenza remain largely uncharacterized in Cambodia. In December 2006, we established passive hospital-based surveillance to identify the causes of acute undifferentiated fever in patients seeking healthcare. Fever was defined as tympanic membrane temperature >38°C. From December 2006 to December 2008, 4233 patients were screened for influenza virus by real-time reverse-transcriptase polymerase chain reaction (rRT–PCR). Of these patients, 1151 (27·2%) were positive for influenza. Cough (68·8% vs. 50·5%, P<0·0001) and sore throat (55·0% vs. 41·9%, P<0·0001) were more often associated with laboratory-confirmed influenza-infected patients compared to influenza-negative enrollees. A clear influenza season was evident between July and December with a peak during the rainy season. Influenza A and B viruses were identified in 768 (66·3%) and 388 (33·7%) of the influenza-positive population (n=1153), respectively. In December 2008, passive surveillance identified infection of the avian influenza virus H5N1 in a 19-year-old farmer from Kandal province who subsequently recovered. From a subset of diagnostic samples submitted in 2007, 15 A(H1N1), seven A(H3N2) and seven B viruses were isolated. The predominant subtype tested was influenza A(H1N1), with the majority antigenically related to the A/Solomon Island/03/2006 vaccine strain. The influenza A(H3N2) isolates and influenza B viruses analysed were closely related to A/Brisbane/10/2007 or B/Ohio/01/2005 (B/Victoria/2/87-lineage) vaccine strains, respectively. Phylogenetic analysis of the HA1 region of the HA gene of influenza A(H1N1) viruses demonstrated that the Cambodian isolates belonged to clade 2C along with representative H1N1 viruses circulating in SE Asia at the time. These viruses remained sensitive to oseltamivir. In total, our data suggest that viral influenza infections contribute to nearly one-fifth of acute febrile illnesses and demonstrate the importance of influenza surveillance in Cambodia.</div></front></TEI><affiliations><list><country><li>Cambodge</li><li>Indonésie</li><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li></region></list><tree><country name="Indonésie"><noRegion><name sortKey="Blair, P J" sort="Blair, P J" uniqKey="Blair P" first="P. J." last="Blair">P. J. Blair</name></noRegion><name sortKey="Kasper, M R" sort="Kasper, M R" uniqKey="Kasper M" first="M. R." last="Kasper">M. R. Kasper</name><name sortKey="Putnam, S D" sort="Putnam, S D" uniqKey="Putnam S" first="S. D." last="Putnam">S. D. Putnam</name></country><country name="Cambodge"><noRegion><name sortKey="Wierzba, T F" sort="Wierzba, T F" uniqKey="Wierzba T" first="T. F." last="Wierzba">T. F. Wierzba</name></noRegion><name sortKey="Touch, S" sort="Touch, S" uniqKey="Touch S" first="S." last="Touch">S. Touch</name><name sortKey="Vonthanak, S" sort="Vonthanak, S" uniqKey="Vonthanak S" first="S." last="Vonthanak">S. Vonthanak</name></country><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Xu, X" sort="Xu, X" uniqKey="Xu X" first="X." last="Xu">X. Xu</name></region><name sortKey="Garten, R J" sort="Garten, R J" uniqKey="Garten R" first="R. J." last="Garten">R. J. Garten</name><name sortKey="Klimov, A I" sort="Klimov, A I" uniqKey="Klimov A" first="A. I." last="Klimov">A. I. Klimov</name><name sortKey="Okomo Adhiambo, M A" sort="Okomo Adhiambo, M A" uniqKey="Okomo Adhiambo M" first="M. A." last="Okomo-Adhiambo">M. A. Okomo-Adhiambo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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